This autobiography relates Rush's experiences in college and medical school; his meetings with notable doctors; his life in Scotland, England, and France; his medical views; the military and politics during the Revolutionary War; and brief sketches of personalities of that period.

These photostats are selections from the original manuscript, which is a portion of a volume entitled "Letters, facts, and observations upon a variety of subjects." The topics include medicine, slavery, the African church, gossip and social events, the deaths of prominent Philadelphians, and Rush's philosophy on various subjects. Contains questions for Alexander McGillivray, on diseases, mortality, passions of Creek Indians.